| 摘要 |
Described, in certain aspects, are devices and methods for treating fistulae. In one embodiment, a fistula plug includes a hydratable component and hydration resistant component incorporated on or in the hydratable component. Illustratively, an inventive plug can include a first component and a second component, wherein the first component is hydratable, and the second component is less receptive to hydration than the first component (or is essentially non- hydratable). Either of these components may be formed with one or more of a variety of biocompatible materials including some that are naturally derived and some that are non-naturally derived. In one embodiment, the first component and the second component, while dissimilar in their receptivity to hydration, are both comprised of a remodelable, angiogenic material, for example, a remodelable extracellular matrix material such as submucosa.
|
