发明名称 |
RESISTANT MUTANT 90 kDA HEAT SHOCK PROTEIN |
摘要 |
An object to be solved by the present invention is to identify patients resistant to known HSP90 inhibitors, and to provide a novel therapeutic agent for treating the patients who have become resistant to known HSP90 inhibitors. As a means for solving the above problems, the present invention provides identification of the patients based on a protein, which is an HSP90 family protein having a mutation in the site corresponding to F138 of HSP90± class A consisting of the amino acid sequence of SEQ ID NO: 1, and use of a substance that inhibits the protein as an active ingredient of a therapeutic agent. |
申请公布号 |
EP3064582(A1) |
申请公布日期 |
2016.09.07 |
申请号 |
EP20140850588 |
申请日期 |
2014.10.02 |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD. |
发明人 |
YOSHIMURA, CHIHOKO;KODAMA, YASUO;OHKUBO, SHUICHI |
分类号 |
C12N15/09;A61K31/437;A61K45/00;A61P25/28;A61P31/12;A61P35/00;A61P37/06;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;G01N33/15;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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