发明名称 Method of Estimating Antitumor Effect of Histone Deacetylase Inhibitor
摘要 The present invention provides a method of obtaining a gene capable of becoming an index for predicting the efficacy of a histone deacetylase inhibitor, which comprises at least (I) a step of dividing tumor cells into a histone deacetylase inhibitor sensitive tumor cell and a histone deacetylase inhibitor resistant tumor cell, and (II) a step of examining the gene expression pattern of each of the sensitive tumor cell and the resistant tumor cell, and a step of selecting (i) a gene showing high expression in the sensitive tumor cell and low expression in the resistant tumor cell, or (ii) a gene showing low expression in the sensitive tumor cell and high expression in the resistant tumor cell, in order to provide a gene useful for predicting the efficacy, particularly an antitumor effect, of a histone deacetylase inhibitor, for a tumor desired to be treated.
申请公布号 US2008233562(A1) 申请公布日期 2008.09.25
申请号 US20040546285 申请日期 2004.02.10
申请人 ASTELLAS PHARMA INC. 发明人 SASAKAWA YUKA;NAOE YOSHINORI
分类号 C12Q1/68;A61K38/12;G01N33/50 主分类号 C12Q1/68
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