发明名称 |
STABLE ANTIBODY FORMULATIONS |
摘要 |
The present invention provides formulations and methods for the stabilization of antibodies. In one embodiment, the invention provides the stable solution formulation of an IgG1 antibody that specifically binds to insulin-like growth factor-I receptor. In another embodiment, the invention provides methods of stabilization of IgG1 antibody that specifically binds to insulin-like growth factor-I receptor comprising lyophilizing an aqueous formulation of the antibody. The formulations can be lyophilized to stabilize the antibodies during processing and storage, and then the formulations can be reconstituted for pharmaceutical administration. |
申请公布号 |
WO2008116103(A3) |
申请公布日期 |
2009.01.08 |
申请号 |
WO2008US57718 |
申请日期 |
2008.03.20 |
申请人 |
IMCLONE SYSTEMS INCORPORATED;SRIVASTAVA, ARVIND;GOLDSTEIN, JOEL |
发明人 |
SRIVASTAVA, ARVIND;GOLDSTEIN, JOEL |
分类号 |
A61K39/395;C07K16/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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