Method and Device for Monitoring Medication Usage

摘要

The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is an analytical testing device and related computer-assisted products for detecting and quantifying metabolites in a biological sample efficiently and accurately.

主权项

1. A method of determining a drug dose taken by a subject, the method comprising:
(a) determining a concentration of a test metabolite and a reference metabolite in a biological sample obtained from a subject, wherein the test metabolite is the drug or a metabolite of the drug; (b) determining the normalized concentration of the test metabolite in the biological sample as a ratio of the concentration of the test metabolite to the concentration of the reference metabolite; and (c) determining the drug dose taken by the subject by using a database to determine the drug dose that is correlated with the normalized concentration of the test metabolite obtained in step (b), wherein the database comprises (i) dose of the drug taken by a reference population; (ii) reference metabolite concentration in a medium of biological sampling obtained from the reference population, and (iii) test metabolite concentration in the medium of biological sampling obtained from the reference population.