摘要 |
<p>A pharmaceutical composition comprising crystalline S-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate.camsylate as an active ingredient is provided to prevent vascular disease related to platelet, inhibit thrombus and improve bioavailability of the active ingredient by enhancing stability, non-hydroscopic property and optical purity. The pharmaceutical composition for preventing vascular disease related to platelet and inhibiting thrombus comprises 8.61-344.4mg of crystalline S-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate.camsylate represented by the formula(I) as an active ingredient and further comprises pharmaceutically acceptable excipients, binders, disintegrant or lubricants, wherein the crystalline S-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate.camsylate is prepared by reacting a compound represented by the formula(III) with a compound represented by the formula(VI) in a polar or nonpolar organic solvent selected from acetic acid ethyl, acetonitrile, methanol, ethanol, isopropanol and t-butanol at 0-200 deg. C.</p> |