The present invention provides technology for making large (e.g., greater than 50 amino acids), semi-synthetic, stapled or stitched proteins. The method essentially involves ligating a synthetically produced stapled or stitched peptide to a larger protein. Modified version of IL-13 and MYC are provided as illustrative examples.
申请公布号
WO2010011313(A2)
申请公布日期
2010.01.28
申请号
WO2009US04260
申请日期
2009.07.23
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;VERDINE, GREGORY, L.;KENNEDY, EILEEN, JEANNE
