The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10 DAB with a bridging silicon-based protecting group. The resulting 7,10 protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.
申请公布号
WO2006135692(A2)
申请公布日期
2006.12.21
申请号
WO2006US22335
申请日期
2006.06.08
申请人
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.;VU, PHONG;HOLTON, ROBERT, A.
