发明名称 |
Methods to enhance and confine expression of genes |
摘要 |
The present invention provides a novel approach to gene therapy of restricted areas such as tumors. The methods introduced here comprise: (a) placing a gene of interest in a plasmid vector driven by a heat or light inducible promoter; (b) modifying this vector by including a tetracycline responsive fusion protein which acts as a transcriptional activator, thus permitting regulation of gene expression by varying the levels of drug and; (c) modifying this vector by including DNA sequences that reduce or eliminate expression of genes in normal bystander cells. Also provided are a set of vectors for both sustained and regulable expression. There is also presented novel vectors for the gene therapy treatment of local and metastatic breast, ovarian and prostate cancer. |
申请公布号 |
ZA200101207(B) |
申请公布日期 |
2007.01.31 |
申请号 |
ZA20010001207 |
申请日期 |
2001.02.13 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
YUEN KAI FUNG;ANNE T'ANG;CHARLES J. GOMER |
分类号 |
C12N15/09;A61K;A61K35/76;A61K38/17;A61K38/19;A61K48/00;A61P35/00;C12N5/10;C12N15/63;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|