发明名称 |
COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE |
摘要 |
Colchicine neoglycosides, method for their synthesis and methods for their use are disclosed. The invention provides analogs of colchicine glycosylated to include a sugar moiety on a colchicine scaffold that is generally unglycosylated in nature. The colchicine neoglycosides disclosed herein are shown to have cytotoxic effects equivalent to at least the known cytotoxins paclitaxel and doxorubicin. Further, the neoglycosides disclosed according to the invention have physiologic effects not previously recognized in the alkaloid family that includes colchicine but recognized in other cytotoxic drug families such as the taxanes which act by stabilizing tubulin formation.
|
申请公布号 |
US2008171787(A1) |
申请公布日期 |
2008.07.17 |
申请号 |
US20070868737 |
申请日期 |
2007.10.08 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
THORSON JON S.;AQEEL AHMED |
分类号 |
A61K31/70;A61K31/35 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|