发明名称 |
BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION |
摘要 |
<p>The present invention provides methods for performing dynamic nuclear polarization using biradicals with a structure of formula (I) as described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a biradical of formula (I) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. The present invention also provides biradicals with a structure of formula (I) with the proviso that Q1 and Q2 are different when X1 and X2 are —O—. The present invention also provides methods for making biradicals with a structure of formula (IA) as described herein.</p> |
申请公布号 |
EP2018545(A2) |
申请公布日期 |
2009.01.28 |
申请号 |
EP20070870172 |
申请日期 |
2007.05.10 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
GRIFFIN, ROBERT G.;HU, KAN-NIAN;SWAGER, TIMOTHY M;SONG, CHANGSIK;DANE, ERIC |
分类号 |
G01N24/12;A01N43/40;C07D207/46;C07D419/12 |
主分类号 |
G01N24/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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