发明名称 |
TGF-β INHIBITORS |
摘要 |
Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein A, X, Z, m, p, and R2 are as described herein. In certain embodiments, a compound disclosed herein inhibits the activity of one or more members of the TGF-β superfamily, and can be used to treat disease by blocking such activity. |
申请公布号 |
WO2016160881(A1) |
申请公布日期 |
2016.10.06 |
申请号 |
WO2016US24840 |
申请日期 |
2016.03.30 |
申请人 |
RIGEL PHARMACEUTICALS, INC. |
发明人 |
GELMAN, Marina;KINSELLA, Todd;BHAMIDIPATI, Somasekhar;DARWISH, Ihab;SINGH, Rajinder;YU, Jiaxin |
分类号 |
C07D401/04;A61K31/4162;A61K31/425;A61P5/00;A61P9/00;A61P11/00;A61P13/00;A61P15/00;A61P17/00;A61P19/00;A61P25/00;A61P27/00;A61P35/00;C07D403/04;C07D417/04 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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