发明名称 |
PLATE FOR SELECTION OF ANTIBIOTICS AGAINST BIOFILM INFECTIONS |
摘要 |
This invention is a diagnostic plate that can be used to select antibiotic combinations with efficacy against microorganisms growing as a biofilm. The plate allows growth of biofilm on a plurality of projections, and the subsequent simultaneous challenge of biofilms on all projections of the plate to independent concentrations and combinations of anti-biofilm agents. Resistance of microorganisms to antibiotics is higher when they grow as a biofilm, as compared to when they grow in a planktonic state which is usually used to determine their level of antibiotic sensitivity. Growth of microorganims that slough off the biofilm in the anti-biofilm agent challenge determines the Minimum Inhibitory Concentration (MIC) which relates to sensitivity of the microorganisms in a planktonic state. Growth of any surviving microorganims from the biofilm in a subsequent recovery step determines the Minimal Biofilm Eradication Concentration (MBEC) which relates to the sensitivity of the micoorganisms growing as a biofilm. Enumeration of the surviving microorganims in the recovery step determines the Minimum Biocidal Concentration (MBC).
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申请公布号 |
KR20080081891(A) |
申请公布日期 |
2008.09.10 |
申请号 |
KR20087004354 |
申请日期 |
2006.07.24 |
申请人 |
INNOVOTECH, INC. |
发明人 |
OLSON MERLE E.;CERI HOWARD |
分类号 |
C12Q1/18;C12M1/34;C12N1/20;C12Q1/02 |
主分类号 |
C12Q1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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