摘要 |
In various embodiments, the present invention provides methods, compositions, dosing, and administration schedules for treatment of autoimmune diseases, including systemic erythematosus (SLE), for example, comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule such as atacicept. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BLyS and APRIL, in particular the use of multiple administrations of the fusion molecule at relatively low dose over the course of the treatment. |
申请人 |
ZYMOGENETICS, INC.;ARES TRADING S.A.;BUSBY, SHARON J.;GROSS, JANE A.;VISICH, JENNIFER;NESTOROV, IVAN;MUNAFO, ALAIN;PAPASOULIOTIS, ORESTIS;PENA ROSSI, CLAUDIA |
发明人 |
BUSBY, SHARON J.;GROSS, JANE A.;VISICH, JENNIFER;NESTOROV, IVAN;MUNAFO, ALAIN;PAPASOULIOTIS, ORESTIS;PENA ROSSI, CLAUDIA |