QUINOLINE-CARBOXYLIC ACID-AMIDE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND ANTIBIOTIC COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

摘要

An antibacterial composition containing a quinoline-carboxylic acid amide derivative or its pharmaceutically allowable salt is provided to suppress bacteria proliferation by inhibiting Fab I activation which is related to the last step of fatty acid biosynthesis. An antibacterial composition comprises a quinoline-carboxylic acid-amide derivative of the chemical formula 1 or its pharmaceutically allowable salt. A method for manufacturing the quinoline-carboxylic acid-amide derivative comprises: a step of reacting an aldehyde group of the chemical formula 2 with a phosphate, whose cyano group is substituted, to obtain a compound of the chemical formula 3; a step of performing intramolecular cyclization of the compound of the chemical formula 3 to obtain a quinoline compound of the chemical formula 4; a step of reacting the compound of the chemical formula 4 with a secondary amine to obtain a compound of the chemical formula 1(1a); and a step of reacting the compound of the chemical formula 1(1a) with an isocyanate to obtain the compound of the chemical formula 1.