CROSS-LINKED PEG POLYMER COATING FOR IMPROVING BIOCOMPATIBILITY OF MEDICAL DEVICES

摘要

The present invention relates to a cross-linked PEG polymer coating that is hydrophilic, lubricious, and resistant to adsorption of biological matters including proteins and cells. The coating is created using plasma glow discharge polymerization of organic compounds with a formula R(OCH2CH2)nOH, where R is an alkane group with 1-4 carbon atoms and n=1-6.

主权项

1. A device comprising a substrate and a coating composition, said coating composition being produced by, i) providing a monomer source comprising one or more chemical compounds, wherein at least one chemical compound is R(OCH2CH2)nOH, where R is an alkane group with 1-4 carbon atoms and n=1-6; ii) creating a plasma of the monomer source; and iii) contacting at least a portion of a substrate with the plasma to provide a plasma polymer coated surface wherein the plasma polymer coated surface is hydrophilic, lubricious, and has the characteristics of resisting protein adsorption and cell adhesion.