HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS

摘要

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds.

主权项

1. A compound having Structure I:or a pharmaceutically acceptable salt thereof, wherein:
L-Ar is Ar is R1 is H, —CN, halogen, C1-C4 alkyl, —O—(C3-C5 cycloalkyl), —O-(4- to 6-membered heterocycle) or —O—(C1-C4 alkyl), wherein when R1 is not H, —CN or halogen, R1 is optionally substituted with one or more halogen; each R2 is independently hydrogen, halogen or C1-C4 alkyl; R3 is H or F; R21 is H, halogen, C1-C4 alkyl, C3-C5 cycloalkyl or 4- to 6-membered heterocycle; R22 is H, halogen or C1-C2 alkyl; R24 is —O—(C1-C4 alkyl), —O—(C1-C4 alkyl)-O—(C1-C4 alkyl), —O—(C3-C5 cycloalkyl), or —O-(4- to 6-membered heterocycle), wherein R24 is optionally substituted with one or more hydroxyl or halogen; and R25 is H, halogen, C1-C4 alkyl or C3-C5 cycloalkyl, wherein R25 is optionally substituted with one or more halogen;wherein the compound is not: