| 主权项 |
1. A 2-hetarylpyridazinone derivative of the formula (I) or salt thereof in which Q is Q1 or Q2, R1 is hydrogen, halogen, cyano, amino, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-cycloalkenyl, (C2-C6)-alkynyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C3)-alkyl, (C1-C6)-alkoxy-(C2-C6)-alkoxy, (C1-C6)-alkoxy-(C2-C6)-alkoxy-(C1-C3)-alkyl, (C1-C6)-alkyl-S(O)n, halo-(C1-C6)-alkyl-S(O)n, (C1-C6)-alkyl-S(O)n—(C1-C3)-alkyl, halo-(C1-C6)-alkyl-S(O)n—(C1-C3)-alkyl, (C1-C6)-alkylamino or (C1-C6)-dialkylamino, R2 is hydrogen, halogen, cyano, hydroxyl, nitro, amino, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkyl-S(O)n, halo-(C1-C6)-alkyl-S(O)n, (C1-C6)-alkyl-S(O)n—(C1-C3)-alkyl, halo-(C1-C6)-alkyl-S(O)n—(C1-C3)-alkyl, (C1-C6)-alkylamino or (C1-C6)-dialkylamino, R3 is hydrogen, (C1-C6)-alkylcarbonyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkyl-S(O)n, (C1-C6)-alkyl-S-carbonyl, arylcarbonyl or aryl-S(O)n, where the two latter radicals are each substituted by s R4 radicals, R4 is halogen, (C1-C4)-alkyl, halo-(C1-C4)-alkyl or (C1-C4)-alkoxy, X1 is N or CZ1, X2 is N or CW, X3 is N or CR5, X4 is N or CY2, Y1 is (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C2-C6)-alkenyl, halo-(C2-C6)-alkenyl, (C2-C6)-alkynyl, halo-(C3-C6)-alkynyl, (C3-C6)-cycloalkyl, halo-(C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, halo-(C3-C6)-cycloalkyl-(C1-C6)-alkyl, OCOOR6, OC(O)N(R6)2, OR6, OCOR6, OSO2R7, (C1-C6)-alkyl-S(O)nR7, (C1-C6)-alkyl-OR6, (C1-C6)-alkyl-OCOR6, (C1-C6)-alkyl-OSO2R7, (C1-C6)-alkyl-CO2R6, (C1-C6)-alkyl-SO2OR6, (C1-C6)-alkyl-CON(R6)2, (C1-C6)-alkyl-CN, (C1-C6)-alkyl-SO2N(R6)2, (C1-C6)-alkyl-NR6COR6, (C1-C6)-alkyl-NR6SO2R7, CH2P(O)(OR10)2, (C1-C6)-alkylaryl, (C1-C6)-alkylheteroaryl, (C1-C6)-alkylheterocyclyl, where the three latter radicals are each substituted by s radicals from the group consisting of halogen, cyano, nitro, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, S(O)n—(C1-C6)-alkyl, (C1-C6)-alkoxy and halo-(C1-C6)-alkoxy, and where heterocyclyl bears n oxo groups, Y2 is hydrogen, nitro, halogen, cyano, thiocyanato, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C2-C6)-alkenyl, halo-(C2-C6)-alkenyl, (C2-C6)-alkynyl, halo-(C2-C6)-alkynyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkenyl, halo-(C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, halo-(C3-C6)-cycloalkyl-(C1-C6)-alkyl, COR1, COOR1, OCOOR1, NR1COOR1, C(O)N(R1)2, NR1C(O)N(R1)2, OC(O)N(R1)2, CO(NOR1)R1, NR1SO2R2, NR1COR1, OR1, OSO2R2, S(O)nR2, SO2OR1, SO2N(R1)2 (C1-C6)-alkyl- S(O)nR2, (C1-C6)-alkyl-OR1, (C1-C6)-alkyl-OCOR1, (C1-C6)-alkyl-OSO2R2, (C1-C6)-alkyl-CO2R1, (C1-C6)-alkyl-CN, (C1-C6)-alkyl-SO2OR1, (C1-C6)-alkyl-CON(R1)2, (C1-C6)-alkyl-SO2N(R1)2, (C1-C6)-alkyl-NR1COR1, (C1-C6)-alkyl-NR1SO2R2, N(R1)2, P(O)(OR5)2, CH2P(O)(OR5)2, (C1-C6)-alkylphenyl, (C1-C6)-alkylheteroaryl, (C1-C6)-alkylheterocyclyl, phenyl, heteroaryl or heterocyclyl, where the six latter radicals are each substituted by s radicals from the group consisting of halogen, nitro, cyano, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C3-C6)-cycloalkyl, S(O)n—(C1-C6)-alkyl, (C1-C6)-alkoxy, halo-(C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C4)-alkyl and cyanomethyl, and where heterocyclyl bears n oxo groups, Z1 is hydrogen, halogen, cyano, thiocyanato, nitro, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C2-C6)-alkenyl, halo-(C2-C6)-alkenyl, (C2-C6)-alkynyl, halo-(C2-C6)-alkynyl, (C3-C6)-cycloalkyl, halo-(C3-C6)-cycloalkyl, (C1-C6)-alkyl-(C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, halo-(C3-C6)-cycloalkyl-(C1-C6)-alkyl, COR6, COOR6, OR6, OCOOR6, NR6COOR6, C(O)N(R6)2, NR6C(O)N(R6)2, OC(O)N(R6)2, C(O)NR6OR6, OSO2R7, S(O)nR7, SO2OR6, SO2N(R6)2, NR6SO2R7, NR6COR6, (C1-C6)-alkyl-S(O)nR7, (C1-C6)-alkyl-OR6, (C1-C6)-alkyl-OCOR1, (C1-C6)-alkyl-OSO2R7, (C1-C6)-alkyl-CO2R6, (C1-C6)-alkyl-SO2OR6, (C1-C6)-alkyl-CON(R6)2, (C1-C6)-alkyl-SO2N(R6)2, (C1-C6)-alkyl-NR6COR6, (C1-C6)-alkyl-NR1SO2R7, N(R6)2, P(O)(OR10)2, heteroaryl, heterocyclyl or phenyl, where the three latter radicals are each substituted by s radicals from the group consisting of halogen, nitro, cyano, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C3-C6)-cycloalkyl, S(O)n—(C1-C6)-alkyl, (C1-C6)-alkoxy and halo-(C1-C6)-alkoxy, and where heterocyclyl bears n oxo groups, Z2 is (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C2-C6)-alkenyl, halo-(C2-C6)-alkenyl, (C2-C6)-alkynyl, halo-(C2-C6)-alkynyl, (C3-C6)-cycloalkyl, halo-(C3-C6)-cycloalkyl, (C1-C6)-alkyl-(C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, halo-(C3-C6)-cycloalkyl-(C1-C6)-alkyl, COR6, COOR6, OR6, OCOOR6, NR6COOR6, C(O)N(R6)2, NR6C(O)N(R6)2, OC(O)N(R6)2, C(O)NR6OR6, OSO2R7, S(O)nR7, SO2OR6, SO2N(R6)2, NR6SO2R7, NR6COR6, (C1-C6)-alkyl-S(O)nR7, (C1-C6)-alkyl-OR6, (C1-C6)- alkyl-OCOR1, (C1-C6)-alkyl-OSO2R7, (C1-C6)-alkyl-CO2R6, (C1-C6)-alkyl-SO2OR6, (C1-C6)-alkyl-CON(R6)2, (C1-C6)-alkyl-SO2N(R6)2, (C1-C6)-alkyl-NR6COR6, (C1-C6)-alkyl-NR1SO2R7, N(R6)2, heteroaryl, heterocyclyl or phenyl, where the three latter radicals are each substituted by s radicals from the group consisting of halogen, nitro, cyano, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C3-C6)-cycloalkyl, S(O)n—(C1-C6)-alkyl, (C1-C6)-alkoxy and halo-(C1-C6)-alkoxy, and where heterocyclyl bears n oxo groups, W is hydrogen, halogen, cyano, nitro, (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C2-C6)-alkenyl, (C2-C6)-haloalkenyl, (C2-C6)-alkynyl, (C2-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-halocycloalkyl, (C1-C6)-alkyl-O—(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C1-C4)-alkoxy or (C1-C4)-haloalkoxy, or Z1 or Z2 and W together with the two carbon atoms to which they are bonded form a five- or six-membered ring consisting oft carbon atoms and p heteroatoms from the group consisting of N, O and S, where this ring is substituted by q radicals from the group consisting of halogen, nitro, cyano, (C1-C6)-alkyl, halo-(C1-C6)-alkyl, (C3-C6)-cycloalkyl, S(O)n—(C1-C6)-alkyl, (C1-C6)-alkoxy, halo-(C1-C6)-alkoxy and (C1-C6)-alkoxy-(C1-C6)-alkyl, R5 is hydrogen, halogen, (C1-C4)-alkyl, halo-(C1-C4)-alkyl or (C1-C4)-alkoxy, R6 is hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C2-C6)-alkenyl, (C2-C6)-haloalkenyl, (C2-C6)-alkynyl, (C2-C6)-haloalkynyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkenyl, (C3-C6)-halocycloalkyl, (C1-C6)-alkyl-O—(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, phenyl, phenyl-(C1-C6)-alkyl, heteroaryl, (C1-C6)-alkylheteroaryl, heterocycyl, (C1-C6)-alkylheterocyclyl, (C1-C6)-alkyl-O-heteroaryl, (C1-C6)-alkyl-O-heterocyclyl, (C1-C6)-alkyl-NR8-heteroaryl or (C1-C6)-alkyl-NR8-heterocyclyl, where the 21 latter radicals are substituted by s radicals from the group consisting of cyano, halogen, nitro, thiocyanato, OR8, S(O)nR9, N(R8)2, NR8OR8, COR8, OCOR8, SCOR9, NR8COR8, NR8SO2R9, CO2R8, COSR9, CON(R8)2 and (C1-C4)-alkoxy-(C2-C6)-alkoxycarbonyl, and where heterocyclyl bears n oxo groups, R7 is (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkenyl, (C1-C6)-alkyl-O—(C1-C6)-alkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, phenyl, phenyl-(C1-C6)-alkyl, heteroaryl, (C1-C6)-alkylheteroaryl, heterocyclyl, (C1-C6)-alkyl-heterocyclyl, (C1-C6)-alkyl-O-heteroaryl, (C1-C6)-alkyl-O-heterocyclyl, (C1-C6)-alkyl-NR3-heteroaryl or (C1-C6)-alkyl-NR3-heterocyclyl, where these 17 radicals are substituted by s radicals from the group consisting of cyano, halogen, nitro, thiocyanato, OR8, S(O)nR9, N(R8)2, NR8OR8, COR8, OCOR8, SCOR9, NR8COR8, NR8SO2R9, CO2R8, COSR9, CON(R8)2 and (C1-C4)-alkoxy-(C2-C6)-alkoxycarbonyl, and where heterocyclyl bears n oxo groups, R8 is hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl or phenyl, R9 is (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl or phenyl, R10 is (C1-C4)-alkyl, n is 0, 1 or 2, p is 0, 1, 2 or 3, q is 0, 1, 2, 3 or 4 s is 0, 1, 2, 3, 4 or 5, t is 0, 1, 2, 3, 4, 5 or 6. |
