发明名称 |
NON-INTEGRATING VIRAL DELIVERY SYSTEM AND METHODS OF USE THEREOF |
摘要 |
The present invention relates generally to non-integrating viral delivery system and methods of using the same. The viral delivery systems includes a viral carrier, a heterologous viral episomal origin of replication, a sequence encoding at least one initiator protein specific for the heterologous viral episomal origin of replication, and at least one gene, shRNA, siRNA, miRNA, or other gene-silencing RNA of interest. In certain embodiments, the disclosed system can be used for gene therapy. |
申请公布号 |
WO2016200997(A1) |
申请公布日期 |
2016.12.15 |
申请号 |
WO2016US36519 |
申请日期 |
2016.06.08 |
申请人 |
AMERICA GENE TECHNOLOGIES INTERNATIONAL, INC. |
发明人 |
PAUZA, Charles, David;LAHUSEN, Tyler |
分类号 |
C12N15/86;A61K48/00;C12N15/113;C12N15/867 |
主分类号 |
C12N15/86 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|