THERAPEUTIC PASTES FOR MEDICAL DEVICE COATING

摘要

This invention provides a high-solids therapeutic composition for coating a medical device comprising: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the composition is in a singular stable phase. Also provided is a mold-cast medical device, said medical device comprising a cured mixture of : (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the mixture forms a high-solids device. In a preferred embodiment, the first material is ssDNA, the second material a styrene-isobutylene-styrene triblock copolymer SIBS and the emulsifying agent F127 Poloxamer.