COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING PHENYL-AMINO-THIAZOLONE DERIVATIVES OR PHAMACEUTICALLY ACCEPTABLE SALTS THEREOF INHIBITING PROTEIN PHOSPHATASE AS AN ACTIVE INGREDIENT

摘要

A composition containing phenylaminothiazolone derivative or its pharmaceutically allowable salt for preventing and treating cancer is provided to suppress protein phosphatase activation and cancer cell division and proliferation. A composition for preventing and treating cancer, which suppress a protein phosphatase comprises a phenylaminothiozolone derivative of the chemical formula 1 or its pharmaceutically allowable salt as an active ingredient. The salt is an acid addition salt which is formed by free acid. The acid addition salt is produced by resolving the derivative of the chemical formula 1 in excess of acid solution and precipitating the salt in organic solvent. The protein phosphatase is Cdc25A[cell division cycle 25A], Cdc25B, Cdc25C, PTP1B[protein tyrosine phosphatase 1B], Prl-3[phosphatase of regenerating liver], LAR[leukocyte antigen-related], CD45[cluster of differentiation 45], Yop[Yersinia enterocolytica tyrosine phosphatase], PP1[protein phosphatases 1], or VHR[vaccinia human-related].