MODIFICATION OF RECOMBINANT ADENOVIRUS WITH IMMUNOGENIC PLASMODIUM CIRCUMSPOROZOITE PROTEIN EPITOPES

摘要

PROBLEM TO BE SOLVED: To provide recombinant adenoviral vaccine for augmenting immune response and circumventing pre-existing immunity to adenovirus.SOLUTION: Provided is a recombinant adenovirus vaccine derived from a recombinant adenovirus plasmid vector. The recombinant adenovirus plasmid vector comprises a nucleotide sequence encoding a Plasmodium circumsporozoite protein or antigenic portion thereof operably linked to a heterologous promoter and a nucleotide sequence encoding one or more modified capsid proteins or core proteins, where an immunogenic epitope of the Plasmodium circumsporozoite protein is inserted into or replaces at least part of the one or more modified capsid proteins and/or core proteins.SELECTED DRAWING: None