| 发明名称 |
LIPID BIOMARKERS OF HEALTHY AGEING |
| 摘要 |
In one aspect there is provided a method for predicting a risk of unhealthy ageing in a subject, comprising: (a) determining a level of two or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from two or more of the following groups: (i) a triacylglycerol (TAG) from TAG (46:5) to TAG (54:3); (ii) an ether phosphatidylcholine (PC-O) from PC-O(28:0) to PC-O(38:6); (iii) a sphingomyelin (SM) from SM (33:1) to SM(50:1); (iv) a phosphatidylcholine (PC) from PC (32:1) to PC (40:5); (v) a phosphatidylinositol (PI) from PI (36:1) to PI (38:3); (vi) a phosphatidylethanolamine (PE) from PE (36:2) to PE (38:4); and (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of the risk of unhealthy ageing in the subject. |
| 申请公布号 |
US2016245786(A1) |
申请公布日期 |
2016.08.25 |
| 申请号 |
US201415028244 |
申请日期 |
2014.11.05 |
| 申请人 |
NESTEC S.A. |
发明人 |
Collino Sebastiano;Montoliu Roura Ivan;Martin Françios-Pierre;Beguelin Fiona Camille;Rezzi Serge André Dominique |
| 分类号 |
G01N33/487 |
主分类号 |
G01N33/487 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for predicting a risk of unhealthy ageing in a subject, comprising:
(a) determining a level of two or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from two or more of the following groups:
(i) a triacylglycerol (TAG) from TAG(46:1) to TAG(54:6);(ii) an ether phosphatidylcholine (PC-O) from PC-O(28:0) to PC-O(38:6);(iii) a sphingomyelin (SM) from SM(33:1) to SM(50:4);(iv) a phosphatidylcholine (PC) from PC(32:1) to PC(40:5);(v) a phosphatidylinositol (PI) from PI(36:1) to PI(38:3);(vi) a phosphatidylethanolamine (PE) from PE(36:2) to PE(38:4); and (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of the risk of unhealthy ageing in the subject. |
| 地址 |
Vevey CH |
