| 摘要 |
The inventions relate to the pharmaceutical industry, including pharmaceutical compositions forming the base of gels, and methods for producing gels which are intended mainly for preventing and/or treating anal fissures, haemorrhoids and diseases associated therewith and for reducing sensations of pain after a haemorrhoidectomy. The inventions relate to compositions and preparation methods, and also to the use of gels including nifedipine and lidocaine hydrochloride. The gels are prepared using nanotechnology. The technical result is achieved by producing such a composition of a gel including nifedipine and lidocaine hydrochloride, each variant of which provides for robustness of the gel properties, transparency, and preservation of the stability of the properties for up to 2 years, and the use of which makes it possible to reduce the clinical symptoms of haemorrhoids, up to and including complete elimination of said symptoms, to heal an anal fissure, and to relieve pain syndrome, including after a haemorrhoidectomy. Furthermore, the technical result is achieved by creating such a method for preparing a gel including nifedipine and lidocaine hydrochloride using nanotechnology, which provides for robustness of the gel properties, transparency, and preservation of the stability of the properties for up to 2 years. All the proposed inventions are industrially applicable, and laboratory tests have shown that the presented subject matter is practically implementable and will be extensively used in the pharmaceutical industry. |
