| 发明名称 |
METHODS AND COMPOSITIONS FOR TREATMENT OF CARTILAGE AND DISC TISSUE PATHOLOGIES |
| 摘要 |
An isolated polypeptide comprising a peptide selected from: i) DHX1SDNYT, wherein X1 is L or H (SEQ ID NO:3); ii) a conservative variant of i) iii) a fragment of i) or ii); wherein the conservative variant and/or fragment retains biological activity and the peptide is 15 or less amino acids as well as recombinant cells, and uses thereof. |
| 申请公布号 |
US2016207959(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201414914452 |
申请日期 |
2014.08.27 |
| 申请人 |
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY |
发明人 |
MWALE Fackson;ANTONIOU John;HAGLUND Lisbet;ROUGHLEY Peter J.;GAWRI Rahul;EPURE Laura M.;GRANT Michael P. |
| 分类号 |
C07K7/06;A61K35/28;A61K35/32 |
主分类号 |
C07K7/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated polypeptide comprising a peptide selected from:i) DHX1X2X3 X4X5X6;(SEQ ID NO: 1) X1 is any amino acid, optionally L, H, R Q; X2 is S or L; X3 is D, S or N; X4 is N or D; X5 is Y or S; and/or X6 is T or Y ii) a conservative variant of i) iii) a fragment of i) or ii); wherein the conservative variant and/or fragment retains biological activity and the peptide is 15 or less amino acids. |
| 地址 |
Montreal CA |
