发明名称 |
ANTIGEN-BINDING MOLECULE CONTAINING MODIFIED ANTIBODY VARIABLE REGION |
摘要 |
The present inventors have successfully prepared an antigen-binding molecule comprising an antibody variable region that has binding activity against a molecule expressed on the surface of a T cell and a molecule expressed on the surface of any other immunocyte, but does not bind to these molecules at the same time. The present invention allows the preparation of an antigen-binding molecule capable of circumventing adverse reactions that may be caused by the cross-linking of T cells to other immunocytes, and provides an antigen-binding molecule suitable as a drug. |
申请公布号 |
EP3070168(A1) |
申请公布日期 |
2016.09.21 |
申请号 |
EP20140859814 |
申请日期 |
2014.11.11 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;KADONO, SHOJIRO;HIRONIWA, NAOKA;SAKURAI, MIKA |
分类号 |
C12N15/09;A61K39/395;A61P35/00;C07K16/28;C07K16/30;C07K16/46 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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