发明名称 |
TC-83-DERIVED ALPHAVIRUS VECTORS, PARTICLES AND METHODS |
摘要 |
The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs. |
申请公布号 |
US2016348132(A1) |
申请公布日期 |
2016.12.01 |
申请号 |
US201615234949 |
申请日期 |
2016.08.11 |
申请人 |
ALPHAVAX, INC. |
发明人 |
RAYNER Jon O.;SMITH Jonathan F.;HUBBY Bolyn;REAP Elizabeth A. |
分类号 |
C12N15/86;A61K39/21;A61K39/00;C12N7/00;C07K14/005;A61K39/12 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Research Triangle Park NC US |