| 主权项 |
1. A nucleoside of formula (1):or isomers thereof, wherein:
one of D1 and D2 is H, or a hydroxyl protecting group, and the other of D1 and D2 is H, a hydroxyl protecting group, or a reactive phosphorus group; m is an integer from 1 to 15; B is selected from the group consisting of hydrogen, unsubstituted or substituted aliphatic, a natural nucleobase, a modified nucleobase, and a universal nucleobase; Q is selected from the group consisting of O, S, NR10, and CH2; W is absent, O, S or NR′; V is a straight or branched, substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, or substituted or unsubstituted alkynylene, of which one or more methylenes can be interrupted by O, S, S(O), SO2, N(R′), C(O), phosphorus containing linkage, aryl, heteroaryl, heterocyclic, or cycloalkyl; R′ is hydrogen, acyl, unsubstituted or substituted aliphatic; Z is selected from the group consisting of OR10, COR10, CO2R10,NR20R30, CONR20R30, CON(H)NR20R30, ONR20R30, CON(H)N═CR40R50, N(R20)C(═NR30)NR20R30, N(R20)C(O)NR20R30, N(R20)C(S)NR20R30, OC(O)NR20R30, SC(O)NR20R30, N(R20)C(S)OR10, N(R20)C(O)OR10, N(R20)C(O)SR10, N(R20)N═CR40R50, ON═CR40R50, SO2R10, SOR10, SR10, and substituted or unsubstituted heterocyclic;
R20 and R30 for each occurrence are independently selected from the group consisting of hydrogen, acyl, unsubstituted or substituted aliphatic, aryl, heteroaryl, heterocyclic, OR10, COR10, CO2R10, and NR10R10′; or R20 and R30 are taken together with the atom to which they are bound to form an unsubstituted or substituted heterocyclic ring; R40 and R50 for each occurrence are independently selected from the group consisting of hydrogen, acyl, unsubstituted or substituted aliphatic, aryl, heteroaryl, heterocyclic, OR10, COR10, CO2R10, and NR10R10′; and R10 and R10′ are each independently hydrogen, unsubstituted or substituted aliphatic, aryl, heteroaryl, or heterocyclic; provided that when W is O and Z is OR10, V is not an unsubstituted alkylene or an unsubstituted alkoxylene. |
