CHEMICAL ENGINEERING PROCESSES AND APPARATUS FOR THE SYNTHESIS OF COMPOUNDS

摘要

The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase.;;Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.

主权项

1. A system for producing cannabinoids comprising:
a fermentor holding a cell culture medium comprising genetically modified cells producing and secreting a cannabinoid synthase into the medium; a bioreactor containing a reaction mixture configured to interact with the cannabinoid synthase to form one or more cannabinoids; and a control mechanism configured to regulate a property of the medium containing the cannabinoid synthase or to control a property of the reaction mixture;
wherein the property of the reaction mixture is one or more of the ionic strength of the reaction, the pH of the reaction, the temperature of the reaction, or the pressure of the reaction.