摘要 |
<p>The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.</p> |
申请人 |
DSM IP ASSETS BV;VRIES DE, ANDREAS, HENDRIKUS, MARIA;VERZIJL, GERARDUS, KAREL, MARIA;HERMSEN, PETRUS, JOHANNES;CASTELIJNS, ANNA, MARIA, CORNELIA, FRANCISCA |
发明人 |
VRIES DE, ANDREAS, HENDRIKUS, MARIA;VERZIJL, GERARDUS, KAREL, MARIA;HERMSEN, PETRUS, JOHANNES;CASTELIJNS, ANNA, MARIA, CORNELIA, FRANCISCA |