Engineered Lumenized Vascular Networks and Support Matrix

摘要

Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.

主权项

1. A device for fabrication of engineered capillary networks comprising:
living cells; a cell-culture surface; and a support-generating medium, the support-generating medium comprising a gel forming material and a liquid cell-culture medium, wherein the gel forming material is substantially dissolved in the cell-culture medium and forms a support medium on the cell-culture surface.