METHOD FOR PRODUCING HETEROCYCLIC COMPOUND

摘要

There is provided a method for producing with a high efficiency a heterocyclic compound that is useful as a raw material for pharamaceuticals. A novel production method for producing 2,2,7,9-tetramethyl-2H-pyrano[2,3-g]quinoline (compound (6)) that has a quinoline ring and a chromene ring using N-(3-acetyl-4-hydroxyphenyl)butylamide (compound (1′)) that is commercially available as a raw material for pharamaceuticals or the like as a starting raw material; and a method for purifying compound (6), characterized by purifying by subjecting it to conversion into a salt form.;

主权项

1. A method for producing 2,2-dimethyl-2H-chromen-6-amine comprising the following steps (a) to (d) (in the following formulae (1) to (4), R1 is a C1-6 alkyl group):
(a) reacting a compound of Formula (1):with acetone to obtain a chromanone ring derivative of Formula (2): (b) reducing the obtained chromanone ring derivative to obtain an alcohol derivative of Formula (3): (c) dehydrating the obtained alcohol derivative to obtain a chromene ring derivative of Formula (4): and (d) hydrolyzing the obtained chromene ring derivative to obtain 2,2-dimethyl-2H-chromen-6-amine of Formula (5).