| 主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of (C1-C8)alkyl, (C1-C8)haloalkyl, hydroxy, (C1-C8)alkoxy, (C5-C12)aryl, 5-12 membered heteroaryl, (C3-C10)cycloalkyl, 3-12 membered heterocyclyl, OR4, SR4 and N(R4)2, where each R4 is independently A-R14, where A is absent, (C1-C3)alkyl, —C(O)— or —SO2—, and R14 is hydrogen, (C1-C8)alkyl, (C5-C12)aryl, 5-12 membered heteroaryl, (C3-C10)cycloalkyl or 3-12 membered heterocyclyl, or two R4 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S; R2 is hydrogen, halogen, (C1-C8)alkyl, hydroxy, (C1-C8)alkoxy or N(R5)2, where each R5 is independently hydrogen or (C1-C8)alkyl, or two R5 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S; R3 is hydrogen, hydroxy or NH2, or R3 is absent if m is 0; Q is absent or is a divalent moiety selected from O, S, NH and (C1-C8)alkylene; U is selected from the group consisting of OR6, SR6, N(R6)2, (C1-C8)alkyl-N(R6)2, (C5-C12)aryl, 5-12 membered heteroaryl, (C3-C10)cycloalkyl, 3-12 membered heterocyclyl, (C1-C8)alkyl, (C1-C8)heteroalkyl and (C1-C8)haloalkyl, where U is not CH2-hydroxy if m+n=0, and where U is not hydroxy if m+n=1 and R3 is hydrogen, where U is optionally substituted with one or more substituents each independently selected from (C1-C8)alkyl, (C1-C8)alkyl-N(R6)2, O(C2-C8)alkyl-N(R6)2, (C1-C8)haloalkyl, hydroxy, (C1-C8)alkoxy, halogen, (C5-C12)aryl, 5-12 membered heteroaryl, (C3-C10)cycloalkyl, 3-12 membered heterocyclyl, OR6, N(R6)2 and SO2R6, and where each R6 is independently hydrogen, (C1-C8)alkyl, (C1-C8)alkyl-N(R7)2 where each R7 is hydrogen or (C1-C8)alkyl, (C5-C12)aryl, 5-12 membered heteroaryl, (C3-C10)cycloalkyl or 3-12 membered heterocyclyl, or two R6 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S; V is N or C, where if V forms a double bond V is carbon; W is N or C, where if W forms a double bond W is carbon; X is N or C where if X forms a double bond X is carbon; Y is CR10, N, NR10, O or S, where each R10 is independently selected from hydrogen, (C1-C8)alkyl, hydroxy, (C1-C8)alkoxy, halogen, SH, S—(C1-C8)alkyl and N(R11)2 if Y is CR10, where Y forms a double with an adjacent ring member when Y is CR10 or N, and where each R11 is independently hydrogen, (C1-C5)alkyl, (C5-C12)aryl or 5-12 membered heteroaryl or two R11 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S, or Y is C(R10)2 and the two R10 and the carbon to which they are associated form a carbonyl or a thiocarbonyl; Z is CR12, N, NR12, O or S, where each R12 is independently selected from hydrogen, (C1-C8)alkyl, hydroxy, (C1-C8)alkoxy, fluoro, chloro, bromo, SH, S—(C1-C8)alkyl and N(R13)2, where Z forms a double bond with an adjacent ring member if it is CR12 or N, where each R13 is independently hydrogen, (C1-C8)alkyl, (C5-C12)aryl or 5-12 membered heteroaryl, or two R13 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S, and where Z is not NR12 if X is N, V is C, W is C and Y is CR10, or Z is C(R12)2 and the two R12 and the carbon to which they are associated form a carbonyl or a thiocarbonyl; each is an optional bond, where no more than two non-adjacent may be present; m is 0-1; and n is 0-1. |
