| 摘要 |
The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of M1 and M3, but have no significant effect on M2 receptor subtype, and the above compounds are characterized by rapid action, long-lasting efficacy, and low toxic and side-effects when used to treat rhinitis, post-cold rhinitis, chronic trachitis, airway hyperresponsiveness, asthma, chronic obstructive pulmonary diseases, cough, urinary incontinence, frequent urination, unstable bladder syndrome, bladder spasms, bladder inflammation and gastrointestinal diseases such as irritable bowel syndrome, spastic colitis, as well as duodenal and gastric ulcers. |
| 主权项 |
1. A compound shown by formula I: or a pharmaceutically acceptable salt, solvate, prodrug or optical isomer thereof, wherein in formula I: n is selected from 1˜7, R1 is a C3-C7 hydrocarbyl, which can be unsubstituted, or can further, without limitation, be optionally substituted by halogen, alkoxy, alkoxyhydrocarbyl, heterocyclyl, or aryl, R2 is an aryl, which can be unsubstituted, or further be optionally substituted, R3 is a hydroxyl, halogen, alkoxy or acyloxy, wherein the alkoxy or acyloxy can be unsubstituted, or can further, without limitation, be optionally substituted by halogen, hydroxyl, alkoxy, hydrocarbyl, alkoxyhydrocarbyl, heterocyclyl, or aryl; R4 and R5 can be present or absent, and are independently selected from the substituents of halogen, hydroxyl, alkoxy, hydrocarbyl, alkoxyhydrocarbyl, heterocyclyl, aryl, and the like, when present; Y is a linear or branched C1-C7 alkyl or —(CH2—O—CH2)m—, which can be optionally substituted, wherein m is equal to 1-3, X− is an acid radical or hydroxyl. |
