Crystalline naloxol-PEG conjugate

摘要

Naloxol-polyethylene glycol conjugates of the formula:;
are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.

主权项

1. A crystalline phosphate salt of mPEG7-O-naloxol having XRPD d values of (Å) comprising 21.0; 12.1; 7.9; 6.5; 5.3; 4.83; 4.24; 3.81; and 3.75.