INTRATHECAL ADMINISTRATION, PREFERABLY INTRAVENTRICULAR, OF MTOR INHIBITORS FOR THE THERAPY OF SOME NEURODEGENERATIVE, NEUROINFLAMMATORY AND NEURO-ONCOLOGIC DISEASES

摘要

The invention relates to the use of inhibitors of the enzyme mTOR kinase (mammalian target of rapamycin) in the treatment of neuro-oncologic diseases, in particular tuberous sclerosis, neurodegenerative diseases, in particular Alzheimer's disease, and neuroinflammatory diseases, in particular multiple sclerosis and primary progressive aphasia, via intrathecal, or preferably intraventricular, administration of said inhibitors.

主权项

1. A method for the treatment of Alzheimer's disease comprising intrathecally administering an effective amount of everolimus to a patient in need thereof, wherein said intrathecal administration is an intraventricular administration within the lateral ventricles.