摘要 |
<p>This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1- naphthalenamine or 1,2,3,4-tetrahydro-l-naphthalenamine substructure.</p> |
申请人 |
SEPRACOR INC.;ZHAO, HANG;KOENIG, STEFAN, G.;VANDENBOSSCHE, CHARLES, P.;SINGH, SURENDRA, P.;WILKENSON, SCOTT, H.;BAKALE, ROGER, P. |
发明人 |
ZHAO, HANG;KOENIG, STEFAN, G.;VANDENBOSSCHE, CHARLES, P.;SINGH, SURENDRA, P.;WILKENSON, SCOTT, H.;BAKALE, ROGER, P. |