FRIZZLED-BINDING AGENTS AND USES THEREOF

摘要

PROBLEM TO BE SOLVED: To provide novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors.SOLUTION: Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.