Molecular constructs for treating tumors

摘要

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

主权项

1. A molecular construct comprising,
a pair of CH2-CH3 segments of an IgG.Fc; a first pair of effector elements, wherein the effector element is a drug bundle comprising a plurality of cytotoxic drug molecules, and the first pair of effector elements is linked to the C-termini of the pair of CH2-CH3 segments; and a first pair of targeting elements, wherein the targeting element is an antibody fragment specific for a cell surface antigen selected from the group consisting of CD5, CD19, CD20, CD22, CD23, CD30, CD33, CD34, CD37, CD38, CD43, CD78, CD79a, CD79b, CD138, and CD319, and the first pair of targeting elements is linked to the N-termini of the pair of CH2-CH3 segments.