发明名称 |
New Use |
摘要 |
The present invention relates to methods and pharmaceutical compositions for renal protection in a mammal in need thereof, such as a mammal having a disease manifested by atrial enlargement and/or remodeling or suffering from hypertension or heart failure or being prone to suffering from hypertension and/or heart failure, comprising administration of a therapeutically effective amount, or a prophylactically effective amount, of an Angiotensin Receptor Neprilysin inhibitor (ARNi) or of a combination of an Angiotensin Receptor Blocker (ARB) with a Neutral Endopeptidase inhibitor (NEPi) or with a NEPi pro-drug to said mammal. |
申请公布号 |
US2016206597(A1) |
申请公布日期 |
2016.07.21 |
申请号 |
US201314914029 |
申请日期 |
2013.08.26 |
申请人 |
Bransford Toni Lynne;BURKEY Bryan;LANGENICKEL Thomas;LEFKOWITZ Martin;SHI Victor Chengwei |
发明人 |
Bransford Toni Lynne;BURKEY Bryan;LANGENICKEL Thomas;LEFKOWITZ Martin;SHI Victor Chengwei |
分类号 |
A61K31/41;A61K31/216 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
1. A method for the protection of the kidney of a mammal suffering from hypertension or heart failure or being prone to suffering from hypertension and/or heart failure comprising administering to said mammal in need of such protection a pharmaceutical composition comprising a therapeutically effective amount of
a) the compound trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3′-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate] hemipentahydrate (LCZ696), or b) a combination comprising a physical mixture of
(i) valsartan or a pharmaceutically acceptable salt thereof; and(ii) N-(3-carboxy-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methylbutanoic acid ethyl ester or a pharmaceutically acceptable salt thereof,in a 1:1 molar ratio. |
地址 |
Upper Montclair NJ US |