| 摘要 |
A method of conferring a cooling effect on the skin or mucous membranes by applying thereto at least one compound of the Formula I: (a) wherein B is selected from H, CH<sub>3</sub>, C<sub>2</sub>H<sub>5</sub>, OCH<sub>3</sub>, OC<sub>2</sub>H<sub>5</sub>; and OH; and (b) wherein A is a moiety of the formula -CO-D, wherein D is selected from the following moieties: (i) -NR<sup>1</sup>R<sup>2</sup>, wherein R<sup>1</sup> and R<sup>2</sup> are independently selected from H and C<sub>1</sub>-C<sub>8</sub> straight or branched-chain aliphatic, alkoxyalkyl, hydroxyalkyl, araliphatic and cycloalkyl groups, or R<sup>1</sup> and R<sup>2</sup> together with the nitrogen atom to which they are attached form part of an optionally-substituted, five- or six-membered heterocyclic ring; (ii) -NHCH<sub>2</sub>COOCH<sub>2</sub>CH<sub>3</sub>, -NHCH<sub>2</sub>CONH<sub>2</sub>, -NHCH<sub>2</sub>CH<sub>2</sub>OCH<sub>3</sub>, -NHCH<sub>2</sub>CH<sub>2</sub>OH, -NHCH<sub>2</sub>CH(OH)CH<sub>2</sub>OH and (iii) a moiety selected from the group consisting of: The compounds are useful for providing cooling effects in a variety of products, such as foodstuffs, confectionery, tobacco products, beverages, cosmetics, dentifrices, medicinal preparations, mouthwashes and toiletries. |
