| 摘要 |
The present invention relates to recombinant human interferon-beta-1b (~IFN- beta-1b~) polypeptides, or fragments analogs, derivatives, or variants thereof, having an improved specific activity. The present invention also relates to pharmaceutical compositions comprising such IFN-beta-1b polypeptides. or fragments, analogs, derivatives, or variants therof, useful for treating multiples sclerosis. The present invention further relates to methods of producing such IFN-beta-1b compositions.
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