发明名称 Stable Anti-inflammatory Solutions for Injection
摘要 The present invention relates to stable liquid formulations of ketoprofen, amitriptyline, and oxymetazoline.
申请公布号 US2016166696(A1) 申请公布日期 2016.06.16
申请号 US201514971154 申请日期 2015.12.16
申请人 Omeros Corporation 发明人 Demopulos Gregory A.;Gombotz Wayne R.;Shen Hui-rong
分类号 A61K47/12;A61K31/137;A61K9/00;A61K47/10;A61K47/18;A61K31/192;A61K31/4174 主分类号 A61K47/12
代理机构 代理人
主权项 1. A liquid pharmaceutical formulation comprising 550 μM to 1 M ketoprofen, 55 μM to 1 M amitriptyline, 350 μM to 1 M oxymetazoline, 1-100% (v/v) polyol, and 10-500 mM Na citrate, pH 4.5-7.0, wherein the ketoprofen, amitriptyline, and oxymetazoline are soluble, and wherein the ketoprofen, amitriptyline, oxymetazoline are stable for at least six months when stored at a temperature of between 2° C. and 30° C.
地址 Seattle WA US