发明名称 |
NEW PRECURSOR MIRNA AND APPLICATIONS IN TUMOR THERAPY THEREOF |
摘要 |
Provided are a new precursor miRNA and the applications in tumor therapy thereof. The precursor miRNA, from 5'- to 3'-end thereof, has the structure represented by formula (I). B1 is an anti-miRNA and/or siRNA to be expressed; B2 is a sequence substantially or completely complementary to B1, and B2 is not complementary to C; C is a sequence with stem-loop structure; A1 and A2 are independently hydrogen or optionally a RNA sequence consisting of 4 to 5 bases. The precursor miRNA can be processed to form an anti-miRNA and/or siRNA in hosts. |
申请公布号 |
WO2016177343(A1) |
申请公布日期 |
2016.11.10 |
申请号 |
WO2016CN81195 |
申请日期 |
2016.05.05 |
申请人 |
JIANGSU MICROMEDMARK BIOTECH CO., LTD. |
发明人 |
ZHANG, Chenyu;ZENG, Ke;CHEN, Xi;ZHANG, Junfeng;LIANG, Hongwei |
分类号 |
A61K48/00;A61K31/7088;A61P35/00;C12N15/113;C12N15/63 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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