发明名称 |
Methods for Superdisintegrant-Based Composite Particles for Dispersion and Dissolution of Active Pharmaceutical Agents |
摘要 |
The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g., micro-particle formulations) and enhance the recovery of the nanoparticles of active agents during aqueous re-dispersion and their dissolution rate in vitro and in vivo. |
申请公布号 |
US2016346209(A1) |
申请公布日期 |
2016.12.01 |
申请号 |
US201615235397 |
申请日期 |
2016.08.12 |
申请人 |
New Jersey Institute of Technology |
发明人 |
Bilgili Ecevit;Dave Rajesh;Bhakay Anagha;Azad Mohammad |
分类号 |
A61K9/14;B05D7/24;A61K31/343;A61J3/02;A61K31/216 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
1. A method for fabricating colloidal and ultrafine superdisintegrant (SDI) particles comprising:
providing SDI particles; wet-milling the SDI particles in a wet media mill to form colloidal and ultrafine SDI particles; wherein the wet-milled SDI particles have a particle size of less than about 5 microns. |
地址 |
Newark NJ US |