| 摘要 |
Described herein are pharmaceutical compositions for the treatment of sexual dysfunction in an individual In some embodiments, the pharmaceutical composition includes a prolactin variant having a glycine residue at position 129 substituted with an amino acid other than glycine. In one embodiment, the amino acid is arginine. In one embodiment, the prolactin variant further comprises an N-terminal deletion. In one embodiment, the prolactin variant is conjugated to a H(OCH2CH2)nOH molecule (e.g., a equals any number from 1 to 6). In some embodiments, the pharmaceutical composition is delivered to the individual by a. microneedle patch or an inhalable formulation. |
