摘要 |
The invention encompasses a process for granulating particles that produces homogeneous, free flowing, attrition resistant, uniform sized granules using a Wurster unit operation (Fig. 1). When utilized with active pharmaceutical ingredients, such granules can be further processed into controlled released or taste- masked pharmaceutical formulations. Particularly, the process can be utilized to make an oral granule formulation of etoricoxib for treating pain and inflammation in patients that cannot swallow a tablet, such as young children and the elderly.
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申请人 |
MERCK & CO INC;MERCK FROSST CANADA LTD.;HO, JENNIFER, S.;DUMONT, HUBERT;MANCINELLI, CHRISTOPHER;SHELUKAR, SUHAS, D. |
发明人 |
HO, JENNIFER, S.;DUMONT, HUBERT;MANCINELLI, CHRISTOPHER;SHELUKAR, SUHAS, D. |