1,4 BENZOTHIAZINE-2-ACETIC ACID DERIVATIVES, PROCESSES FOR PRODUCTION THEREOF

摘要

1,4-Benzothiazine-2-acetic acid derivatives represented by general formula (I) below: (see formula I) wherein R1 represents a group shown by general formula (II) or (III) (see formula II) (wherein R5 and R6, which may be the same or different, each represents hydrogen, a halogen, lower alkyl group, a lower alkoxyl group, trifluoromethyl or cyano; (see formula III) (wherein R7, R8, R9 and R10, which may be the same or different, each represents hydrogen, a halogen, a lower alkyl group, a lower alkoxyl group or trifluoromethyl); R2 and R3, which may be the same or different, each represents hydrogen, a halogen, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group, trifuloromethyl or trifluoromethoxy; R4 represents carboxyl which may be optionally be esterified; and X represents oxygen or sulfur; and processes for production thereof, as well as a composition for the treatment of diabetic complications and an aldose reductase inhibitor comprising the same.