CONTROLLED RELEASE FORMULATION OF TOLTERODINE

摘要

The invention encompasses stable multiparticulate pharmaceutical compositions of tolterodine having at least one pharmaceutically acceptable excipient and at least two populations of multiparticulates each population having tolterodine or a salt thereof and the ratio of the populations is from 90:10 to 10:90 by weight, wherein after storage for 1 month at 40 °C and 75 % relative humidity the difference between the dissolution profile at 4 hours is no more than about 5 % when compared to the dissolution profile at the time of manufacture.