ALGEBRAIC RECONSTRUCTION OF PERTURBED MODELS OF GENETIC POPULATIONS

摘要

Embodiments are directed to a computer-based simulation system including an input circuit, a memory and a processor system communicatively coupled to the memory and the input circuit. The input circuit is configured to receive an input distribution. The processor system is configured to assign, for each marker of a simulated population matrix, a minor allele frequency. The processor system is further configured to assign, for each marker and each distance of the simulated population matrix, a linkage disequilibrium (LD).

主权项

1. The method of claim 1 further comprising:
using the processor system to constrain each marker of the simulated population matrix based at least in part on the minor allele frequency of the marker and the LD of the marker; wherein the simulated population matrix substantially matches the input distribution.